SCHEMBL29329476

SCHEMBL29329476

N#Cc1ccc(CCNCC(C(=O)Nc2ccc(-c3ccccc3)cn2)c2ccccc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 20/20 0.73
CREBBP Q92793 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21286010 0.89 EP300 (0.77) EP300CREBBP
SCHEMBL22953858 0.87 EP300 (0.77) EP300CREBBP
SCHEMBL21285984 0.85 EP300 (0.54) EP300CREBBP
SCHEMBL21286305 0.85 EP300 (1.00) EP300CREBBP
SCHEMBL30013066 0.85 EP300 (1.00) EP300CREBBP
SCHEMBL23242096 0.85 EP300 (1.00) EP300CREBBP
SCHEMBL21286265 0.85 EP300 (1.00) EP300CREBBP
SCHEMBL29322046 0.84 EP300 (0.76) EP300
SCHEMBL21285724 0.84 EP300 (0.76) EP300CREBBP
SCHEMBL21285865 0.83 EP300 (0.77) EP300

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3752497-B1 P300/CBP HAT INHIBITORS CONSTELLATION PHARMACEUTICALS INC (US) 2024-07-17 EP disclosed