SCHEMBL29329639

SCHEMBL29329639

N#Cc1cc(Oc2cccc(F)c2F)cc(Nc2ccc3cc[nH]c3c2)n1

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MET P08581 1/20 0.43
SYK P43405 3/20 0.39
PRKCQ Q04759 6/20 0.37
TRPA1 O75762 1/20 0.35
ESR1 P03372 4/20 0.34
RET P07949 1/20 0.34
AHR P35869 1/20 0.33
SLC22A12 Q96S37 1/20 0.33
NOTUM Q6P988 1/20 0.32
APP P05067 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29329722 0.89 SYK (0.41) METSYKPRKCQESR1RET
SCHEMBL29329440 0.89 MET (0.40) METSYKPRKCQESR1RET
SCHEMBL29329638 0.87 MET (0.47) METSYKPRKCQTRPA1ESR1
SCHEMBL29329719 0.87 MET (0.41) METSYKPRKCQESR1RET
SCHEMBL29330032 0.87 SYK (0.42) METSYKPRKCQESR1RET
SCHEMBL29329863 0.86 SYK (0.40) METSYKPRKCQESR1RET
SCHEMBL29330255 0.86 ESR1 (0.42) METSYKPRKCQESR1RET
SCHEMBL29329781 0.85 SYK (0.41) METSYKPRKCQESR1RET
SCHEMBL29329536 0.85 SYK (0.40) METSYKPRKCQESR1RET
SCHEMBL29330251 0.84 SYK (0.41) METSYKPRKCQESR1RET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151919-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2024-07-18 WO disclosed