Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 6/20 | 0.47 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21807316 | 0.87 | MKNK1 (0.41) | TRPC5MKNK1PARP1TNKS2PARP2 | |
| SCHEMBL21807357 | 0.87 | TRPC5 (0.51) | TRPC5TRPC4MKNK1PARP1TNKS2 | |
| SCHEMBL21807246 | 0.86 | TRPC5 (0.45) | TRPC5TRPC4MKNK1PARP1TNKS2 | |
| SCHEMBL29329811 | 0.86 | TRPC5 (0.51) | TRPC5TRPC4MKNK1PARP1TNKS2 | |
| SCHEMBL21807317 | 0.85 | TRPC5 (0.46) | TRPC5TRPC4MKNK1PARP1TNKS2 | |
| SCHEMBL21807381 | 0.83 | TRPC5 (0.58) | TRPC5TRPC4MKNK1METNR1H2 | |
| SCHEMBL21807481 | 0.83 | TRPC5 (0.44) | TRPC5TRPC4MKNK1PARP1TNKS2 | |
| SCHEMBL21807469 | 0.80 | TRPC5 (0.44) | TRPC5TRPC4MKNK1PARP1TNKS2 | |
| SCHEMBL31574269 | 0.80 | TRPC5 (0.44) | TRPC5TRPC4MKNK1PARP1TNKS2 | |
| SCHEMBL24433277 | 0.79 | TRPC5 (0.45) | TRPC5TRPC4MKNK1PARP1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4400500-A1 | HALOGEN-SUBSTITUTED PYRIDAZINONE COMPOUND AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2024-07-17 | — | — | EP | disclosed |