Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28448215 | 1.00 | NR1H2 (0.53) | NR1H2NR1H3KMT2ARIPK1UCHL1 | |
| SCHEMBL1778275 | 0.96 | NR1H2 (0.53) | NR1H2NR1H3KMT2ARIPK1UCHL1 | |
| SCHEMBL1778276 | 0.96 | NR1H2 (0.53) | NR1H2NR1H3KMT2ARIPK1UCHL1 | |
| SCHEMBL2169785 | 0.96 | NR1H2 (0.53) | NR1H2NR1H3KMT2ARIPK1UCHL1 | |
| SCHEMBL14880733 | 0.92 | NR1H2 (0.54) | NR1H2NR1H3KMT2ARIPK1UCHL1 | |
| SCHEMBL7486723 | 0.88 | NR1H2 (0.48) | NR1H2NR1H3KMT2ARIPK1UCHL1 | |
| SCHEMBL23646472 | 0.88 | RIPK1 (0.48) | NR1H2NR1H3KMT2ARIPK1UCHL1 | |
| SCHEMBL21611486 | 0.88 | RIPK1 (0.48) | NR1H2NR1H3KMT2ARIPK1UCHL1 | |
| SCHEMBL2130466 | 0.86 | NPC1 (0.48) | NR1H2NR1H3KMT2ARIPK1UCHL1 | |
| SCHEMBL1991706 | 0.86 | RIPK1 (0.47) | NR1H2NR1H3RIPK1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | NR1H2 408/4885NR1H3 280/4885KMT2A 4008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.