Sugi Predict

Sugi Predict / Compounds / SCHEMBL2933242

SCHEMBL2933242

SCHEMBL2933242

Cc1cnccc1CN1C(=O)N(c2ccc(S(=O)(=O)C(F)(F)F)cc2)C(=O)C12CC2

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 3/20 0.53
▸ MCHR1 Q99705 6/20 0.38
▸ CYP3A4 P08684 4/20 0.36
▸ KCNH2 Q12809 5/20 0.35
▸ EBP Q15125 2/20 0.35
▸ LMNA P02545 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ PTGS2 P35354 2/20 0.34
▸ NAMPT P43490 1/20 0.34
▸ EGLN2 Q96KS0 1/20 0.33
▸ EGLN1 Q9GZT9 1/20 0.33
▸ EGLN3 Q9H6Z9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL3724563 0.95 IGF1R (0.49) IGF1RMCHR1CYP3A4KCNH2EBP
SCHEMBL2942132 0.90 IGF1R (0.53) IGF1RMCHR1CYP3A4KCNH2EBP
SCHEMBL3725826 0.89 IGF1R (0.51) IGF1RMCHR1CYP3A4KCNH2EBP
SCHEMBL2940336 0.89 IGF1R (0.51) IGF1RMCHR1CYP3A4KCNH2EBP
SCHEMBL2934554 0.89 IGF1R (0.51) IGF1RMCHR1CYP3A4KCNH2EBP
SCHEMBL2940155 0.88 IGF1R (0.67) IGF1R
SCHEMBL2941189 0.88 IGF1R (0.51) IGF1RMCHR1CYP3A4KCNH2EBP
SCHEMBL2939159 0.88 IGF1R (0.52) IGF1RMCHR1CYP3A4KCNH2EBP
SCHEMBL2936908 0.87 IGF1R (0.50) IGF1RMCHR1CYP3A4KCNH2EBP
SCHEMBL2934666 0.87 IGF1R (0.50) IGF1RMCHR1CYP3A4KCNH2EBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7825115-B2 Cyclic urea compounds, preparation thereof and pharmaceutical use thereof as kinase inhibitors AVENTIS PHARMA S.A. (FR) 2010-11-02 — — US disclosed
EP-1599464-B1 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA SA (FR) 2010-09-22 — — EP disclosed
US-20080108654-A1 Cyclic Urea Compounds, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors AVENTIS PHARMA S.A. (FR) 2008-05-08 — — US disclosed
US-7354933-B2 Protein kinase inhibitors; antitumor agents; such as 5-methyl-1-quinol-4-ylmethyl-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate AVENTIS PHARMA SA (FR) 2008-04-08 — — US disclosed
US-20040248884-A1 Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors AVENTIS PHARMA S.A. (FR) 2004-12-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080108654-A1 Cyclic Urea Compounds, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors PRKG1, PRKACA, CMPK1 IGF1R 1595/4885MCHR1 4505/4885CYP3A4 2988/4885
US-20040248884-A1 Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors PRKG1, PRKACA, PRKCA IGF1R 962/4885MCHR1 4236/4885CYP3A4 2877/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.