Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934060 | 0.87 | ATM (0.44) | ATMCYP3A4CYP1A2CYP2C19CTSS | |
| SCHEMBL2935257 | 0.87 | CNR2 (0.54) | CYP3A4SMN1; SMN2CNR2NPC1RAB9A | |
| SCHEMBL2933395 | 0.86 | CYP3A4 (0.42) | CYP3A4CYP1A2CYP2C19CTSSCTSB | |
| SCHEMBL2934069 | 0.86 | PSMB5 (0.51) | CYP3A4CYP1A2CYP2C19CTSSCTSK | |
| SCHEMBL2934033 | 0.80 | CTSS (0.45) | ATMCTSSCTSBCTSKCTSL | |
| SCHEMBL2932488 | 0.80 | ELANE (0.51) | ATMCYP3A4ERCC1FEN1ERCC4 | |
| SCHEMBL2930110 | 0.79 | NPC1 (0.40) | CTSSCTSKSMN1; SMN2CNR2NPC1 | |
| SCHEMBL2931864 | 0.79 | KMT2A (0.57) | SMN1; SMN2NPC1RAB9AMAPTCNR1 | |
| SCHEMBL2934007 | 0.78 | NPC1 (0.46) | ATMCYP3A4CYP1A2CYP2C19CTSS | |
| SCHEMBL2930834 | 0.78 | SMN1; SMN2 (0.48) | CYP3A4CYP1A2CYP2C19SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846424-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-01-27 | — | — | EP | claimed |