Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31034391 | 1.00 | DYRK1A (0.37) | DYRK1AAURKADAPK3JAK2PRKD3 | |
| SCHEMBL1233902 | 0.80 | HTR6 (0.40) | DYRK1AAURKADAPK3JAK2PRKD3 | |
| SCHEMBL29391023 | 0.80 | HTR6 (0.40) | DYRK1AAURKADAPK3JAK2PRKD3 | |
| SCHEMBL17436172 | 0.79 | MAPK14 (0.37) | DYRK1AAURKADAPK3JAK2PRKD3 | |
| SCHEMBL31034241 | 0.77 | HTR6 (0.35) | DYRK1AAURKADAPK3JAK2PRKD3 | |
| SCHEMBL2076566 | 0.77 | MAPK14 (0.41) | DYRK1AAURKADAPK3JAK2PRKD3 | |
| SCHEMBL29337364 | 0.77 | HTR6 (0.35) | DYRK1AAURKADAPK3JAK2PRKD3 | |
| SCHEMBL1223346 | 0.74 | MAPK14 (0.35) | DYRK1AAURKADAPK3JAK2PRKD3 | |
| SCHEMBL2076592 | 0.73 | MAPK14 (0.45) | DYRK1AAURKADAPK3JAK2PRKD3 | |
| SCHEMBL1224129 | 0.71 | MAPK14 (0.38) | AKR1B1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024148191-A1 | MODULATORS OF TNF-α ACTIVITY | FORWARD THERAPEUTICS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |