Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994431 | 0.87 | NOTUM (0.65) | NOTUMLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL4581611 | 0.81 | TP53 (0.53) | NOTUMLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL17258103 | 0.80 | TP53 (0.56) | NOTUMLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL21152328 | 0.79 | NOTUM (0.72) | NOTUMLMNATP53SMN1; SMN2KMT2A | |
| SCHEMBL29675872 | 0.76 | TP53 (0.55) | LMNAALDH1A1TP53SMN1; SMN2KMT2A | |
| SCHEMBL334619 | 0.76 | LMNA (0.42) | NOTUMLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5330796 | 0.76 | CYP2A6 (0.47) | ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4210419 | 0.75 | KMT2A (0.62) | NOTUMLMNATP53SMN1; SMN2KMT2A | |
| SCHEMBL1353899 | 0.75 | NOTUM (0.60) | NOTUMLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL917714 | 0.75 | NOTUM (0.67) | NOTUMLMNAALDH1A1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365334-B1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2024-07-17 | — | — | EP | disclosed |