Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 16/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17132579 | 0.83 | SMPD3 (0.38) | SMPD3FYN | |
| SCHEMBL22834485 | 0.83 | SMPD3 (0.53) | SMPD3PIM1 | |
| SCHEMBL13975698 | 0.81 | SMPD3 (0.37) | SMPD3PIM1FYNKDM4E | |
| SCHEMBL17132558 | 0.81 | SCN5A (0.43) | SMPD3PIM1FYNKDM4E | |
| SCHEMBL24422759 | 0.77 | SMPD3 (0.34) | SMPD3FYNKDM4E | |
| SCHEMBL18352332 | 0.77 | SCN5A (0.35) | SMPD3FYN | |
| SCHEMBL26142034 | 0.77 | SMPD3 (0.34) | SMPD3FYN | |
| SCHEMBL26141124 | 0.77 | SMPD3 (0.34) | SMPD3FYN | |
| SCHEMBL7460458 | 0.77 | SMPD3 (0.67) | SMPD3PIM1 | |
| SCHEMBL26351968 | 0.76 | TGFBR1 (0.46) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-07-18 | — | — | US | disclosed |
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | KLK5, KLK1, KLKB1 | SMPD3 1404/4885PIM1 4508/4885FYN 2541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.