SCHEMBL2934172

SCHEMBL2934172

O=C(O)CN1C(=O)C(Cc2ccccc2)NC12CCN(C(=O)c1ccccc1F)CC2

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 4/20 0.53
CYP2C19 P33261 4/20 0.53
MAPK14 Q16539 4/20 0.53
HTT P42858 4/20 0.41
TACR1 P25103 1/20 0.40
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 3/20 0.40
TSHR P16473 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PKM P14618 1/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
LMNA P02545 1/20 0.39
HTR2B P41595 3/20 0.39
HSD11B1 P28845 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2941843 0.93 CYP2C9 (0.45) CYP2C9CYP2C19MAPK14HTTTACR1
SCHEMBL2942498 0.87 AVPR1A (0.53) CYP2C9TACR1KDM4EALDH1A1MEN1
SCHEMBL2938363 0.86 CYP2C9 (0.45) CYP2C9CYP2C19MAPK14HTTTACR1
SCHEMBL1800228 0.85 CYP2C9 (0.46) CYP2C9CYP2C19MAPK14HTTTACR1
SCHEMBL2943403 0.84 CYP2C19 (0.44) CYP2C9CYP2C19MAPK14TACR1TSHR
Hydrochloric Acid SCHEMBL1802301 0.84 CYP2C9 (0.45) CYP2C9CYP2C19MAPK14HTTTACR1
SCHEMBL2941530 0.83 HPGD (0.43) ALDH1A1TSHRSMN1; SMN2MEN1KMT2A
SCHEMBL5151456 0.83 CYP2C9 (0.44) CYP2C9CYP2C19MAPK14HTTTACR1
SCHEMBL2938492 0.83 CHRNA4 (0.41) CYP2C9CYP2C19MAPK14ALDH1A1TSHR
SCHEMBL2932813 0.82 MEN1 (0.43) HTTKDM4EALDH1A1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1730147-B1 SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY GRUENENTHAL GMBH (DE) 2010-02-03 EP claimed