Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2941205 | 0.96 | MEN1 (0.44) | MEN1KMT2ATSHRALDH1A1L3MBTL1 | |
| SCHEMBL2938912 | 0.83 | CYP3A4 (0.42) | MEN1KMT2ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL2941530 | 0.82 | HPGD (0.43) | MEN1KMT2ATSHRALDH1A1HPGD | |
| SCHEMBL2943556 | 0.82 | LMNA (0.49) | KMT2AALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2940845 | 0.82 | GRM5 (0.47) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2934172 | 0.82 | CYP2C9 (0.53) | MEN1KMT2ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL2934783 | 0.82 | CCR5 (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1803393 | 0.81 | CCR5 (0.49) | MEN1KMT2ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL4041414 | 0.81 | KMT2A (0.46) | MEN1KMT2ATSHRALDH1A1HPGD | |
| SCHEMBL2934834 | 0.80 | NPC1 (0.48) | TSHRALDH1A1HPGDMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |