Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13515311 | 0.93 | PIM3 (0.54) | TTKBRAFDYRK1ALRRK2PIM3 | |
| Trifluoroacetic Acid SCHEMBL2933929 | 0.87 | PIM3 (0.51) | TTKBRAFDYRK1APIM3RAF1 | |
| SCHEMBL2932525 | 0.87 | LRRK2 (0.46) | TTKBRAFLRRK2 | |
| SCHEMBL13515277 | 0.86 | FASN (0.50) | BRAFPIM3 | |
| SCHEMBL13515300 | 0.85 | MKNK1 (0.46) | BRAF | |
| SCHEMBL2933572 | 0.83 | PIM3 (0.63) | BRAFLRRK2PIM3RAF1 | |
| SCHEMBL2933931 | 0.81 | PIM3 (0.53) | TTKBRAFDYRK1APIM3RAF1 | |
| SCHEMBL2931418 | 0.81 | SRC (0.49) | BRAFDYRK1AIGF1R | |
| SCHEMBL2930788 | 0.81 | KDR (0.50) | TTKDYRK1ALRRK2MAP3K7NUAK1 | |
| Trifluoroacetic Acid SCHEMBL2931457 | 0.81 | FASN (0.46) | DYRK1APIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-B1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB PUBL (SE) | 2010-01-27 | — | — | EP | disclosed |
| EP-2044051-B1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB PUBL (SE) | 2010-01-27 | — | — | EP | disclosed |
| US-20080039450-A1 | Compounds | BIOVITRUM AB (PUBL.) (SE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039450-A1 | Compounds | BIOVITRUM AB (PUBL.) (SE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039450-A1 | Compounds | BIOVITRUM AB (PUBL.) (SE) | 2008-02-14 | — | — | US | disclosed |
| WO-2007147874-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB (PUBL) (SE) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039450-A1 | Compounds | NEK2, CSNK2A3, CSNK2A1 | TTK 266/4885BRAF 524/4885DYRK1A 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.