CSNK2A3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Silmitasertib (SCHEMBL629082)	1.00	8/20
SCHEMBL375140	0.51	7/20
SCHEMBL496829	0.67	6/20
SCHEMBL496943	0.67	6/20
SCHEMBL71021	0.59	6/20
SCHEMBL598301	0.59	6/20
SCHEMBL599578	0.56	6/20
SCHEMBL460780	0.52	6/20
SCHEMBL79794	0.41	6/20
Quercetin (SCHEMBL19723)	1.00	5/20
Quercetin (SCHEMBL118425)	1.00	5/20
Quercetin (SCHEMBL288466)	0.92	5/20
SCHEMBL497030	0.67	5/20
SCHEMBL497031	0.67	5/20
SCHEMBL497247	0.67	5/20
SCHEMBL497249	0.67	5/20
SCHEMBL497258	0.60	5/20
SCHEMBL497260	0.60	5/20
SCHEMBL496866	0.55	5/20
SCHEMBL600296	0.54	5/20

Clinical trials — most relevant to CSNK2A3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
Doxycycline in Human Pulmonary Tuberculosis	PHASE2	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212	EARLY_PHASE1	COMPLETED
Identification of Novel Targetable Kinases in SR-a GvHD	nan	COMPLETED
Study of Metabolic Modifications in Children With Noonan Syndrome	nan	COMPLETED
Nuclear Myosin VI - a Therapeutic Target in Breast Cancer	nan	UNKNOWN
Determining the Association of Chromosomal Variants With Non-PV Triggers and Ablation-outcome in AF (DECAF)	nan	COMPLETED
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex	nan	COMPLETED
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Study of a Candidate Gene Involved in Goldenhar Syndrome.	nan	COMPLETED
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization	nan	COMPLETED
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam	nan	UNKNOWN
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Exploring the Genetics of Neuropathic Pain	nan	RECRUITING
The Relation of Microtubule-Associated Protein 2 and Cell Migration	nan	UNKNOWN
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI	nan	RECRUITING
Immune Signature of Palmoplantar Pustulosis	nan	COMPLETED
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies	nan	ENROLLING_BY_INVITATION
Congenital Uterine Anomalies: Identifying Cancer Associations and Genetic and Environmental Factors to Improve Clinical Care	nan	RECRUITING
Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation	nan	RECRUITING
Corpus Callosum Agenesis and Intellectual Disability	nan	COMPLETED
JAK-STAT Signalling Pathway in Familial Myeloproliferative Disorders	nan	COMPLETED
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Family Blood Pressure Program - GENOA	nan	COMPLETED
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CSNK2A3 binder may also engage these)

Protein	Name	Similarity
P21868	—	1.000	P21868 →
P68399	—	1.000	P68399 →
P28020	—	1.000	P28020 →
CSNK2A1	Casein kinase II subunit alpha	1.000	landscape →
P33674	—	1.000	P33674 →
P19139	—	1.000	P19139 →
Q60737	—	0.999	Q60737 →
P18334	—	0.984	P18334 →
O76484	—	0.983	O76484 →
Q9AR27	—	0.981	Q9AR27 →
B6F107	—	0.981	B6F107 →
P08181	—	0.980	P08181 →
P21869	—	0.975	P21869 →
P28523	—	0.975	P28523 →
O64817	—	0.972	O64817 →
Q8TG13	—	0.971	Q8TG13 →
CSNK2A2	Casein kinase II subunit alpha'	0.969	landscape →
O54833	—	0.968	O54833 →
O42099	—	0.967	O42099 →
Q90327	—	0.967	Q90327 →
Q08467	—	0.966	Q08467 →
Q9DGD9	—	0.966	Q9DGD9 →
Q08466	—	0.966	Q08466 →
P20427	—	0.965	P20427 →
Q91Y86	—	0.963	Q91Y86 →
P40231	—	0.962	P40231 →
O64816	—	0.959	O64816 →
MAPK8	Mitogen-activated protein kinase 8	0.959	landscape →
P49185	—	0.958	P49185 →
P92208	—	0.958	P92208 →