Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 5/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29122050 | 0.91 | CFD (0.44) | CFDICMTPLA2G2AKDM4C | |
| SCHEMBL29121688 | 0.87 | CFD (0.37) | CFDICMTKDM4C | |
| SCHEMBL29122224 | 0.85 | CFD (0.41) | CFDICMTPTGER4 | |
| SCHEMBL29345883 | 0.84 | EGFR (0.35) | CFD | |
| SCHEMBL29123263 | 0.84 | CFD (0.43) | CFDICMT | |
| SCHEMBL29123103 | 0.83 | CFD (0.44) | CFDPTGER4 | |
| SCHEMBL29123168 | 0.83 | CFD (0.42) | CFDICMTPTGER4 | |
| SCHEMBL29123379 | 0.82 | CFD (0.34) | CFDICMTPTGER4 | |
| SCHEMBL29121864 | 0.82 | CFD (0.43) | CFDICMTKDM4CCNR1 | |
| SCHEMBL29122218 | 0.81 | CFD (0.46) | CFDICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | KLK5, KLK1, KLKB1 | CFD 3529/4885ICMT 4826/4885PTGER4 3145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.