Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29348356 | 0.90 | CRBN (0.44) | BRD4CREBBPCRBNDDB1CD274 | |
| SCHEMBL31068168 | 0.88 | DDB1 (0.40) | CRBNDDB1CD274PDCD1 | |
| SCHEMBL29348590 | 0.88 | DDB1 (0.40) | CRBNDDB1CD274PDCD1 | |
| SCHEMBL31068400 | 0.88 | DDB1 (0.40) | CRBNDDB1CD274PDCD1 | |
| SCHEMBL29348338 | 0.83 | PDE10A (0.48) | BRD4CREBBPCRBNDDB1TRPA1 | |
| SCHEMBL29348350 | 0.81 | CRBN (0.49) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL29348431 | 0.81 | CRBN (0.40) | BRD4CREBBPCRBNDDB1CD274 | |
| SCHEMBL29348416 | 0.81 | CRBN (0.47) | CRBNDDB1CD274GPR119 | |
| SCHEMBL29348577 | 0.81 | CRBN (0.44) | CRBNDDB1CD274 | |
| SCHEMBL29348391 | 0.80 | DDB1 (0.39) | CRBNDDB1CD274PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |