Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 10/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31068305 | 1.00 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1NAMPTHPGDCRBN | |
| SCHEMBL29348412 | 0.87 | CREBBP (0.48) | HPGDCRBNDDB1CREBBPBRD4 | |
| SCHEMBL31068121 | 0.86 | CREBBP (0.47) | HPGDCRBNDDB1CREBBPBRD4 | |
| SCHEMBL29348783 | 0.86 | CREBBP (0.47) | HPGDCRBNDDB1CREBBPBRD4 | |
| SCHEMBL31637574 | 0.82 | CRBN (0.44) | CRBNDDB1CREBBPBRD4IKZF3 | |
| SCHEMBL31068259 | 0.82 | CRBN (0.44) | CRBNDDB1CREBBPBRD4IKZF3 | |
| SCHEMBL29349027 | 0.81 | CRBN (0.41) | CRBNDDB1CREBBPBRD4IKZF3 | |
| SCHEMBL31068251 | 0.81 | CRBN (0.41) | CRBNDDB1CREBBPBRD4IKZF3 | |
| SCHEMBL29348667 | 0.78 | CRBN (0.38) | CRBNDDB1IKZF3 | |
| SCHEMBL31068241 | 0.75 | DDB1 (0.56) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |