Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1392957 | 1.00 | MAPT (0.72) | MAPTPOLBADRB1SIRT6CHRNB2 | |
| Hydrochloric Acid SCHEMBL30368622 | 0.98 | MAPT (0.70) | MAPTPOLBADRB1SIRT6CHRNB2 | |
| Hydrochloric Acid SCHEMBL2683957 | 0.98 | MAPT (0.70) | MAPTPOLBADRB1SIRT6CHRNB2 | |
| SCHEMBL5659915 | 0.94 | MAPT (0.74) | MAPTPOLBADRB1SIRT6CHRNB2 | |
| SCHEMBL28101719 | 0.88 | MAPT (0.77) | MAPTPOLBADRB1SIRT6CHRNB2 | |
| Tert-Butyl Formate SCHEMBL27701779 | 0.86 | MAPT (0.55) | MAPTPOLBADRB1SIRT6CHRNB2 | |
| SCHEMBL6363399 | 0.86 | CHRNB2 (0.57) | MAPTPOLBADRB1SIRT6CHRNB2 | |
| SCHEMBL29435521 | 0.85 | MAPT (0.97) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL3539759 | 0.85 | MAPT (0.90) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL15141576 | 0.85 | MAPT (0.97) | MAPTPOLBCHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120092003-A | CDK protein degrading agents, pharmaceutical compositions and therapeutic uses | 拜欧斯瑞克斯公司 | 2025-06-03 | — | — | CN | disclosed |
| WO-2024173646-A1 | CYCLIN-DEPENDENT KINASE DEGRADING COMPOUNDS | INNOVO THERAPEUTICS, INC. (US) | 2024-08-22 | — | — | WO | disclosed |
| CN-111527078-B | Pyridinecarbonyl derivatives and their therapeutic use as TRPC6 inhibitors | 勃林格殷格翰国际公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-113968828-B | Synthesis method of 4- (6-aminopyridine-3-yl) piperazine-1-carboxylic acid tert-butyl ester | 安徽皓元药业有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-113636973-B | Industrial preparation method of 4- (6-aminopyridine-3-yl) piperazine-1-carboxylic acid tert-butyl ester | 山东铂源药业股份有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-113636973-B | Industrial preparation method of 4- (6-aminopyridine-3-yl) piperazine-1-carboxylic acid tert-butyl ester | 山东铂源药业股份有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-115715291-A | Bruton's tyrosine kinase inhibitor and preparation method thereof | 上海华汇拓医药科技有限公司 | 2023-02-24 | — | — | CN | disclosed |
| CN-108290864-B | Protein kinase inhibitor and preparation method and medical application thereof | 甘李药业股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-113968828-A | Synthesis method of 4- (6-aminopyridine-3-yl) piperazine-1-carboxylic acid tert-butyl ester | 安徽皓元药业有限公司 | 2022-01-25 | — | — | CN | disclosed |
| CN-113968828-A | Synthesis method of 4- (6-aminopyridine-3-yl) piperazine-1-carboxylic acid tert-butyl ester | 安徽皓元药业有限公司 | 2022-01-25 | — | — | CN | disclosed |
| CN-113956238-A | Protein kinase inhibitor and preparation method and medical application thereof | 甘李药业股份有限公司 | 2022-01-21 | — | — | CN | disclosed |