Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.52 |
| ▸ | FEN1 | P39748 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.50 |
| ▸ | PDE4A | P27815 | 5/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.50 |
| ▸ | BACE1 | P56817 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513749 | 0.83 | PDE4B (0.54) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL5549968 | 0.81 | ALOX5AP (0.55) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL28039230 | 0.78 | PDE4B (0.50) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL15167033 | 0.78 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL9427603 | 0.77 | ALOX5AP (0.48) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL1513817 | 0.77 | BACE1 (0.52) | ALOX5APFEN1BACE1ALDH1A1ALOX5 | |
| SCHEMBL526920 | 0.76 | ALDH1A1 (0.56) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL29431716 | 0.76 | ALDH1A1 (0.56) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL27625888 | 0.75 | PDE4B (0.50) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL29351964 | 0.75 | BACE1 (0.50) | PDE4BPDE4APDE4CPDE4DBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118994001-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-113966324-B | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-113966324-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2022-01-21 | — | — | CN | disclosed |