Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22529904 | 1.00 | HAO1 (0.46) | HAO1ALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL29353732 | 0.83 | SMN1; SMN2 (0.47) | ALDH1A1HTTLMNASMN1; SMN2HPGD | |
| SCHEMBL22530452 | 0.83 | SMN1; SMN2 (0.47) | ALDH1A1HTTLMNASMN1; SMN2HPGD | |
| SCHEMBL22530819 | 0.81 | S1PR1 (0.41) | ALDH1A1HTTLMNASMN1; SMN2HPGD | |
| SCHEMBL29349939 | 0.81 | S1PR1 (0.41) | ALDH1A1HTTLMNASMN1; SMN2HPGD | |
| SCHEMBL18956900 | 0.77 | MEN1 (0.48) | ALDH1A1HTTLMNAMEN1KMT2A | |
| SCHEMBL30072440 | 0.77 | MEN1 (0.48) | ALDH1A1HTTLMNAMEN1KMT2A | |
| SCHEMBL4596178 | 0.77 | HAO1 (0.49) | HAO1ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL22529936 | 0.76 | HSPB1 (0.59) | HAO1ALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL29351818 | 0.76 | HSPB1 (0.59) | HAO1ALDH1A1HTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118994001-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-113966324-B | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-09-03 | — | — | CN | disclosed |
| EP-3953335-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | Cellestia Biotech AG (CH) | 2022-02-16 | — | — | EP | disclosed |
| CN-113966324-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2022-01-21 | — | — | CN | disclosed |