SCHEMBL29353035

SCHEMBL29353035

CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nc(I)nc2c1ncn2C1CCC(C(=O)O)CC1

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 2/20 0.36
CHKA P35790 15/20 0.34
CHKB Q9Y259 3/20 0.33
ADORA3 P0DMS8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29350248 0.90 CHKA (0.36) CDK1CHKACHKBADORA3
SCHEMBL21176132 0.88 CHKA (0.42) CHKACHKBADORA3
SCHEMBL21176131 0.88 CHKA (0.42) CHKACHKBADORA3
SCHEMBL29354360 0.87 CHKA (0.36) CHKACHKB
SCHEMBL29354564 0.79 CHKA (0.38) CHKACHKB
SCHEMBL21176120 0.79 CHKA (0.45) CHKACHKB
SCHEMBL19820509 0.79 CHKA (0.45) CHKACHKB
SCHEMBL21190300 0.75 CHKA (0.49) CHKACHKBADORA3
SCHEMBL29353246 0.75 CHKA (0.49) CHKACHKBADORA3
SCHEMBL18512572 0.70 PI4KA (0.42) ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109790164-B Purine and 3-deazapurine analogues as choline kinase inhibitors 内尔维亚诺医疗科学公司 2022-01-25 CN disclosed