SCHEMBL29354564

SCHEMBL29354564

COC(=O)C1CCC(n2cnc3c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nc(OC)nc32)CC1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHKA P35790 19/20 0.38
CHKB Q9Y259 4/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29354360 0.91 CHKA (0.36) CHKACHKB
SCHEMBL21176120 0.89 CHKA (0.45) CHKACHKB
SCHEMBL29350248 0.89 CHKA (0.36) CHKACHKB
SCHEMBL19820509 0.89 CHKA (0.45) CHKACHKB
SCHEMBL21176132 0.79 CHKA (0.42) CHKACHKB
SCHEMBL21176131 0.79 CHKA (0.42) CHKACHKB
SCHEMBL29353035 0.79 CDK1 (0.36) CHKACHKB
SCHEMBL19714874 0.74 JAK1 (0.36) CHKA
SCHEMBL21176123 0.72 CHKA (0.47) CHKACHKB
SCHEMBL21176122 0.72 CHKA (0.47) CHKACHKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109790164-B Purine and 3-deazapurine analogues as choline kinase inhibitors 内尔维亚诺医疗科学公司 2022-01-25 CN disclosed