SCHEMBL29353607

SCHEMBL29353607

COC(=O)N(CC(C)(C)NC(=O)OC(C)(C)C)C1(c2ccc(F)c(C(F)(F)F)c2)CC1

nearest known ligand 0.72

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 8/20 0.72
RORC P51449 5/20 0.34
AR P10275 1/20 0.33
DRD2 P14416 2/20 0.32
TAS1R3 Q7RTX0 1/20 0.31
TAS1R1 Q7RTX1 1/20 0.31
TAS1R2 Q8TE23 1/20 0.31
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
AAK1 Q2M2I8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29359283 0.92 KCNN4 (0.72) KCNN4RORCARDRD2AAK1
SCHEMBL22470161 0.91 KCNN4 (0.59) KCNN4RORCARDRD2TAS1R3
SCHEMBL29356770 0.89 KCNN4 (0.76) KCNN4RORCARTAS1R3TAS1R1
SCHEMBL29354486 0.88 KCNN4 (0.55) KCNN4RORCARTAS1R3TAS1R1
SCHEMBL29699684 0.88 KCNN4 (0.74) KCNN4DRD2AAK1
SCHEMBL29353670 0.87 KCNN4 (0.79) KCNN4ARTAS1R3TAS1R1TAS1R2
SCHEMBL29699543 0.85 KCNN4 (0.66) KCNN4RORCDRD2LMNAPOLB
SCHEMBL29353715 0.84 KCNN4 (1.00) KCNN4ARTAS1R3TAS1R1TAS1R2
SCHEMBL29358422 0.84 KCNN4 (0.65) KCNN4RORC
SCHEMBL29356985 0.84 KCNN4 (0.66) KCNN4RORCAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260049054-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA AS (DK) 2026-02-19 US disclosed
US-12391644-B2 Potassium channel inhibitors SANIONA A/S (DK) 2025-08-19 US disclosed
EP-3941903-B1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA AS (DK) 2025-07-16 EP disclosed
US-20240368077-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA AS (DK) 2024-11-07 US disclosed
US-12006289-B2 Potassium channel inhibitors SANIONA A/S (DK) 2024-06-11 US disclosed
US-20220169602-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2022-06-02 US disclosed
EP-3941903-A1 NOVEL POTASSIUM CHANNEL INHIBITORS Saniona A/S (DK) 2022-01-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12391644-B2 Potassium channel inhibitors KCNJ2, KCNN2, KCNN1 KCNN4 48/4885RORC 2789/4885AR 3894/4885
US-20240368077-A1 NOVEL POTASSIUM CHANNEL INHIBITORS KCNN2, KCNJ2, KCNN1 KCNN4 57/4885RORC 2964/4885AR 4214/4885
US-20220169602-A1 NOVEL POTASSIUM CHANNEL INHIBITORS KCNN2, KCNJ2, KCNN1 KCNN4 57/4885RORC 2964/4885AR 4214/4885
US-12006289-B2 Potassium channel inhibitors KCNJ2, KCNN2, KCNN1 KCNN4 48/4885RORC 2789/4885AR 3894/4885
US-20260049054-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SCN10A, KCNK10, KCNJ2 KCNN4 43/4885RORC 4489/4885AR 4183/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.