KCNK10 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1025150	0.49	9/20
SCHEMBL2960950	0.49	9/20
SCHEMBL2310710	0.41	9/20
SCHEMBL1015553	0.57	8/20
SCHEMBL3628210	0.42	7/20
SCHEMBL1160810	0.47	6/20
SCHEMBL2272471	0.55	5/20
SCHEMBL2272483	0.55	5/20
SCHEMBL2270296	0.53	5/20
SCHEMBL2541283	0.47	5/20
SCHEMBL4141917	0.40	5/20
SCHEMBL3620188	0.47	4/20
SCHEMBL381447	0.45	4/20
SCHEMBL4056055	0.42	4/20
SCHEMBL503539	0.39	4/20
SCHEMBL1466665	0.58	3/20
SCHEMBL2274927	0.50	3/20
SCHEMBL3245925	0.50	3/20
SCHEMBL5145298	0.50	3/20
SCHEMBL5145301	0.50	3/20

Clinical trials — most relevant to KCNK10 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery	PHASE4	RECRUITING
Sulphonylurea Receptor Mutation and Responsiveness to Gliclazide - a Pilot Proof of Concept, Randomised Cross-over Study	PHASE4	COMPLETED
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease	PHASE4	NOT_YET_RECRUITING
Mutation-specific Therapy for the Long QT Syndrome	PHASE2	COMPLETED
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy	PHASE1/PHASE2	RECRUITING
Sandostatine® LP and Hyperinsulinism	PHASE2	COMPLETED
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1230 in Pediatric Participants With KCNT1-related Epilepsy	PHASE2	RECRUITING
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients	PHASE2	COMPLETED
An Open-Label Study to Investigate the Safety of Single and Multiple Ascending Doses in Children and Adolescents With Dravet Syndrome	PHASE1/PHASE2	COMPLETED
Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss	PHASE2	COMPLETED
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK	PHASE1	COMPLETED
Peripheral KV7 Activation for Pain Relief	EARLY_PHASE1	COMPLETED
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism	nan	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Qatar Cardiovascular Biorepository of AF Patients	nan	UNKNOWN
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy	nan	UNKNOWN
Interaction of Potassium and Genetic Risk Variants on Diabetes Risk	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)	nan	UNKNOWN
Characteristics of Andersen-Tawil Syndrome	nan	COMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia	nan	UNKNOWN
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development	nan	COMPLETED
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats	nan	COMPLETED
Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients	nan	UNKNOWN
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats	nan	COMPLETED
Characteristics of Episodic Ataxia Syndrome	nan	COMPLETED
Na+ Channel mRNA Regulation in Heart Failure	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KCNK10 binder may also engage these)

Protein	Name	Similarity
Q8BUW1	—	1.000	Q8BUW1 →
Q9JIS4	—	0.998	Q9JIS4 →
KCNK2	Potassium channel subfamily K member 2	0.997	landscape →
Q920B6	—	0.996	Q920B6 →
P34410	—	0.994	P34410 →
Q3LS21	—	0.993	Q3LS21 →
P97438	—	0.992	P97438 →
Q622X0	—	0.990	Q622X0 →
Q9JL58	—	0.990	Q9JL58 →
KCNK9	Potassium channel subfamily K member 9	0.990	landscape →
KCNK3	Potassium channel subfamily K member 3	0.989	landscape →
Q23435	—	0.988	Q23435 →
P97414	—	0.988	P97414 →
Q22271	—	0.988	Q22271 →
Q18120	—	0.987	Q18120 →
Q9ES08	—	0.987	Q9ES08 →
P40310	—	0.987	P40310 →
O97531	—	0.986	O97531 →
A8X8I4	—	0.986	A8X8I4 →
P48767	—	0.986	P48767 →
Q9ER47	—	0.986	Q9ER47 →
SLC8A1	Sodium/calcium exchanger 1	0.986	landscape →
O17185	—	0.986	O17185 →
O54852	—	0.986	O54852 →
P19334	—	0.985	P19334 →
P91682	—	0.985	P91682 →
P48765	—	0.985	P48765 →
Q9QUQ5	—	0.985	Q9QUQ5 →
Q96L42	—	0.984	Q96L42 →
Q63ZI0	—	0.984	Q63ZI0 →