Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNG2 | P59768 | 5/20 | 1.00 |
| ▸ | GNB1 | P62873 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.81 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.77 |
| ▸ | P2RY4 | P51582 | 9/20 | 0.71 |
| ▸ | MET | P08581 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.67 |
| ▸ | P2RY2 | P41231 | 6/20 | 0.67 |
| ▸ | P2RY6 | Q15077 | 4/20 | 0.67 |
| ▸ | ENTPD1 | P49961 | 2/20 | 0.67 |
| ▸ | HGF | P14210 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778161 | 1.00 | GNG2 (1.00) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL3029899 | 0.99 | GNG2 (0.97) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL13021512 | 0.96 | GNG2 (0.92) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL13891732 | 0.93 | GNG2 (0.86) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL13213975 | 0.92 | GNG2 (0.86) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL29357302 | 0.92 | GNG2 (0.85) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL791019 | 0.92 | GNG2 (0.85) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL7765342 | 0.91 | GNG2 (0.84) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL29355106 | 0.91 | GNG2 (0.84) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL10708708 | 0.91 | GNG2 (0.84) | GNG2GNB1CYP1A2CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025073290-A1 | VPS4 INHIBITORS AND METHODS OF USE THEREOF | PARA THERAPEUTICS, INC. (US) | 2025-04-10 | — | — | WO | claimed |
| WO-2022086892-A1 | INTERLEUKIN 4 (IL4)-INDUCED GENE 1 INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2022-04-28 | — | — | WO | claimed |
| EP-3986894-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | Calithera Biosciences, Inc. (US) | 2022-04-27 | — | — | EP | claimed |
| EP-4605397-A1 | HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS | Nuvalent, Inc. (US) | 2025-08-27 | — | — | EP | disclosed |
| EP-4568969-A1 | HETEROAROMATIC MACROCYCLIC ETHER COMPOUNDS | Nuvalent, Inc. (US) | 2025-06-18 | — | — | EP | disclosed |
| CN-120035594-A | Heteroaromatic macrocyclic ether chemotherapeutic agents | 纽威伦特公司 | 2025-05-23 | — | — | CN | disclosed |
| WO-2025073290-A1 | VPS4 INHIBITORS AND METHODS OF USE THEREOF | PARA THERAPEUTICS, INC. (US) | 2025-04-10 | — | — | WO | disclosed |
| WO-2025072117-A1 | HETEROAROMATIC MACROCYCLIC ETHER COMPOUNDS AND ISOTOPOLOGUES THEREOF | NUVALENT, INC. (US) | 2025-04-03 | — | — | WO | disclosed |
| WO-2025072120-A1 | HETEROAROMATIC MACROCYCLIC ETHER COMPOUNDS | NUVALENT, INC. (US) | 2025-04-03 | — | — | WO | disclosed |
| EP-4504189-A1 | METHODS OF TREATING SOLID TUMOR USING (19R)-5-CHLORO-3-ETHYL-16-FLUORO-10,19-DIMETHYL-20-OXA-3,4,10,11,23-PENTAAZAPENTACYCLO[19.3.1.02,6.08,12.013,18]PENTACOSA-1(24),2(6),4,8,11,13,15,17,21(25),22-DECAEN-22-AMINE | Nuvalent, Inc. (US) | 2025-02-12 | — | — | EP | disclosed |
| EP-4504736-A1 | SOLID FORMS, PHARMACEUTICAL COMPOSITIONS AND PREPARATION OF HETEROAROMATIC MACROCYCLIC ETHER COMPOUNDS | Nuvalent, Inc. (US) | 2025-02-12 | — | — | EP | disclosed |
| CN-113811310-B | Compositions comprising phosphorus derivatives of nicotinamide riboside and methods for modulating nicotinamide adenine dinucleotide | 麦德龙国际生物科技有限责任公司 | 2023-03-24 | — | — | CN | disclosed |
| EP-4146626-A2 | HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS | Nuvalent, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |
| EP-4146205-A1 | HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS | Nuvalent, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |
| CN-110234656-B | Exonucleotidase inhibitors and methods of use thereof | 卡利泰拉生物科技公司 | 2023-02-28 | — | — | CN | disclosed |
| WO-2022221227-A1 | AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS | NUVALENT, INC. (US) | 2022-10-20 | — | — | WO | disclosed |
| CN-114555619-A | Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide | 麦德龙国际生物科技有限责任公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2022086892-A1 | INTERLEUKIN 4 (IL4)-INDUCED GENE 1 INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
| EP-3986894-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | Calithera Biosciences, Inc. (US) | 2022-04-27 | — | — | EP | disclosed |
| EP-3941481-A1 | COMPOSITIONS COMPRISING A PHOSPHORUS DERIVATIVE OF NICOTINAMIDE RIBOSIDE AND METHODS FOR MODULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE | Metro International Biotech, LLC (US) | 2022-01-26 | — | — | EP | disclosed |