Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | FADS1 | O60427 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20509670 | 1.00 | NPSR1 (0.50) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL20509859 | 1.00 | NPSR1 (0.50) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL29355343 | 1.00 | NPSR1 (0.50) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL30644716 | 0.99 | NPSR1 (0.49) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL26597491 | 0.99 | NPSR1 (0.49) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL20509675 | 0.99 | NPSR1 (0.49) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL20509792 | 0.90 | KMT2A (0.48) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL20510063 | 0.90 | KMT2A (0.48) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL22446049 | 0.90 | NPSR1 (0.45) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL29656442 | 0.89 | KMT2A (0.52) | NPSR1KMT2AMEN1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240369-A1 | TARGETED CONJUGATES COMPRISING MODIFIED SIRNA | Arbutus Biopharma Corporation (CA) | 2023-09-13 | — | — | EP | disclosed |
| CN-116472063-A | Targeted conjugates comprising modified siRNAs | 阿布特斯生物制药公司 | 2023-07-21 | — | — | CN | disclosed |
| WO-2022098990-A1 | TARGETED CONJUGATES COMPRISING MODIFIED SIRNA | ARBUTUS BIOPHARMA CORPORATION (CA) | 2022-05-12 | — | — | WO | disclosed |
| EP-3941921-A1 | THERAPEUTIC METHODS FOR TREATING HEPATITIS B | Arbutus Biopharma Corporation (CA) | 2022-01-26 | — | — | EP | disclosed |