Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | FADS1 | O60427 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29354583 | 1.00 | NPSR1 (0.50) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL20509670 | 1.00 | NPSR1 (0.50) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL20509859 | 1.00 | NPSR1 (0.50) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL30644716 | 0.99 | NPSR1 (0.49) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL26597491 | 0.99 | NPSR1 (0.49) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL20509675 | 0.99 | NPSR1 (0.49) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL20509792 | 0.90 | KMT2A (0.48) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL20510063 | 0.90 | KMT2A (0.48) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL22446049 | 0.90 | NPSR1 (0.45) | NPSR1KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL29656442 | 0.89 | KMT2A (0.52) | NPSR1KMT2AMEN1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240052349-A1 | TARGETED CONJUGATES COMPRISING MODIFIED SIRNA | ARBUTUS BIOPHARMA CORPORATION (US) | 2024-02-15 | — | — | US | disclosed |
| EP-3601216-B1 | SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDES AND ANALOGS THEREOF, AND METHODS USING SAME FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | ARBUTUS BIOPHARMA CORP (CA) | 2023-10-25 | — | — | EP | disclosed |
| EP-4240369-A1 | TARGETED CONJUGATES COMPRISING MODIFIED SIRNA | Arbutus Biopharma Corporation (CA) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098990-A1 | TARGETED CONJUGATES COMPRISING MODIFIED SIRNA | ARBUTUS BIOPHARMA CORPORATION (CA) | 2022-05-12 | — | — | WO | disclosed |
| EP-3941921-A1 | THERAPEUTIC METHODS FOR TREATING HEPATITIS B | Arbutus Biopharma Corporation (CA) | 2022-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240052349-A1 | TARGETED CONJUGATES COMPRISING MODIFIED SIRNA | SNRPE, AGO2, DCLRE1A | NPSR1 1957/4885KMT2A 317/4885MEN1 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.