SCHEMBL29354598

SCHEMBL29354598

COc1cc2nccc(Cl)c2cc1OCCOC1CCCCO1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
EPHA2 P29317 8/20 0.47
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
KDR P35968 8/20 0.44
EPHB4 P54760 6/20 0.44
EHMT2 Q96KQ7 3/20 0.41
EHMT1 Q9H9B1 3/20 0.41
KDM4C Q9H3R0 1/20 0.41
FGFR1 P11362 2/20 0.41
FLT1 P17948 2/20 0.41
ERBB2 P04626 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SRC P12931 2/20 0.39
ENPP1 P22413 1/20 0.38
KIT P10721 1/20 0.38
PDGFRA P16234 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22441582 1.00 EPHA2 (0.47) EPHA2NPC1RAB9AKDREPHB4
SCHEMBL1098795 0.84 ENPP1 (0.58) EPHA2NPC1RAB9AKDREPHB4
SCHEMBL22445632 0.80 EHMT2 (0.52) EPHA2NPC1RAB9AEHMT2EHMT1
SCHEMBL5177457 0.78 KDM4E (0.54) EPHA2NPC1RAB9AKDREPHB4
SCHEMBL22441517 0.77 EHMT2 (0.49) EPHA2NPC1RAB9AEHMT2EHMT1
SCHEMBL22445494 0.77 EHMT2 (0.49) EPHA2NPC1RAB9AEHMT2EHMT1
SCHEMBL29357291 0.77 EHMT2 (0.49) EPHA2NPC1RAB9AEHMT2EHMT1
SCHEMBL22441436 0.77 KDR (0.60) KDREHMT2EHMT1FGFR1FLT1
SCHEMBL29354537 0.77 KDR (0.60) KDREHMT2EHMT1FGFR1FLT1
SCHEMBL5201839 0.77 KDR (0.60) KDREHMT2EHMT1FGFR1FLT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113924092-B Quinoline and quinazoline compounds and methods of use thereof 斯汀格瑞治疗股份有限公司 2025-03-18 CN disclosed
EP-3941459-A1 QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF Stingray Therapeutics, Inc. (US) 2022-01-26 EP disclosed