Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | LONP1 | P36776 | 9/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.45 |
| ▸ | PSMB11 | A5LHX3 | 5/20 | 0.45 |
| ▸ | PSMA7 | O14818 | 5/20 | 0.45 |
| ▸ | PSMB1 | P20618 | 5/20 | 0.45 |
| ▸ | PSMA1 | P25786 | 5/20 | 0.45 |
| ▸ | PSMA2 | P25787 | 5/20 | 0.45 |
| ▸ | PSMA3 | P25788 | 5/20 | 0.45 |
| ▸ | PSMA4 | P25789 | 5/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 5/20 | 0.45 |
| ▸ | PSMB9 | P28065 | 5/20 | 0.45 |
| ▸ | PSMA5 | P28066 | 5/20 | 0.45 |
| ▸ | PSMB4 | P28070 | 5/20 | 0.45 |
| ▸ | PSMB6 | P28072 | 5/20 | 0.45 |
| ▸ | PSMB10 | P40306 | 5/20 | 0.45 |
| ▸ | PSMB3 | P49720 | 5/20 | 0.45 |
| ▸ | PSMB2 | P49721 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931864 | 0.87 | KMT2A (0.57) | SMN1; SMN2PSMB5PSMB8NPC1RAB9A | |
| SCHEMBL2926141 | 0.85 | RAB9A (0.48) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2935509 | 0.84 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2CTSLLONP1PSMB5 | |
| SCHEMBL2927699 | 0.83 | NPC1 (0.53) | POLBSMN1; SMN2CTSLPSMB5PSMB8 | |
| SCHEMBL609385 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2CTSLLONP1PSMB5PSMB11 | |
| SCHEMBL2936754 | 0.83 | LONP1 (0.69) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL2929287 | 0.82 | NPC1 (0.48) | POLBSMN1; SMN2PSMB5NPC1RAB9A | |
| SCHEMBL2930534 | 0.82 | GRN (0.53) | SMN1; SMN2PSMB5NPC1RAB9AMEN1 | |
| SCHEMBL2931810 | 0.82 | NPC1 (0.45) | POLBSMN1; SMN2PSMB5NPC1RAB9A | |
| SCHEMBL2935265 | 0.82 | NPC1 (0.56) | POLBSMN1; SMN2PSMB5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283367-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2012-10-09 | — | — | US | claimed |
| EP-1846424-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-01-27 | — | — | EP | claimed |
| US-7468383-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2008-12-23 | — | — | US | claimed |
| US-20060189806-A1 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2006-08-24 | — | — | US | claimed |
| US-8283367-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2012-10-09 | — | — | US | disclosed |
| EP-1846424-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-01-27 | — | — | EP | disclosed |
| US-20090075936-A1 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2009-03-19 | — | — | US | disclosed |
| US-7468383-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-20060189806-A1 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189806-A1 | Proteasome inhibitors and methods of using the same | PSMB11, PSMB5, PSMB6 | POLB 836/4885SMN1; SMN2 1069/4885CTSL 1679/4885 |
| US-20090075936-A1 | Proteasome inhibitors and methods of using the same | PSMB11, PSMB5, PSMB6 | POLB 836/4885SMN1; SMN2 1069/4885CTSL 1679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.