Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 7/20 | 0.42 |
| ▸ | CPT1A | P50416 | 2/20 | 0.41 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19208827 | 1.00 | CFD (0.42) | CFDCPT1ACPT1BKDM4EELANE | |
| SCHEMBL25925405 | 0.91 | CFD (0.42) | CFDKDM4EELANETSHRFGFR1 | |
| SCHEMBL12480012 | 0.90 | CFD (0.48) | CFDKDM4EELANETSHRPTGDR2 | |
| SCHEMBL29781834 | 0.89 | CFD (0.51) | CFDCPT1ACPT1BKDM4EELANE | |
| SCHEMBL17023541 | 0.89 | CFD (0.51) | CFDCPT1ACPT1BKDM4EELANE | |
| SCHEMBL29781548 | 0.85 | CFD (0.39) | CFDKDM4ELMNAALDH1A1MAPT | |
| SCHEMBL19208518 | 0.85 | CFD (0.39) | CFDKDM4ELMNAALDH1A1MAPT | |
| SCHEMBL18578337 | 0.81 | CFD (0.46) | CFD | |
| SCHEMBL29545123 | 0.81 | CFD (0.46) | CFD | |
| SCHEMBL18549496 | 0.80 | CFD (0.47) | CFDELANEHSD17B10LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115490751-A | Factor D inhibitors | 拜奥克里斯特制药公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-109121414-B | Benzopyrazole compounds and analogs thereof | 拜奥克里斯特制药公司 | 2022-07-05 | — | — | CN | disclosed |
| EP-3411411-B3 | 1H-INDAZOLE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS FACTOR D INHIBITORS FOR TREATING DISEASES CHARACTERIZED BY ABERRANT COMPLEMENT SYSTEM ACTIVITY, SUCH AS E.G. IMMUNOLOGICAL DISORDERS | BIOCRYST PHARM INC (US) | 2022-01-26 | — | — | EP | disclosed |