Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 5/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22190845 | 1.00 | BRAF (0.49) | BRAFFGFR1WEE1ABL1RIPK2 | |
| SCHEMBL29356085 | 0.88 | ERN1 (0.39) | BRAF | |
| SCHEMBL22191604 | 0.88 | ERN1 (0.39) | BRAF | |
| SCHEMBL25034178 | 0.88 | BRAF (0.62) | BRAFFGFR1ABL1 | |
| SCHEMBL29353158 | 0.87 | ERN1 (0.39) | BRAF | |
| SCHEMBL22191003 | 0.87 | ERN1 (0.39) | BRAF | |
| SCHEMBL22190874 | 0.87 | BRAF (0.50) | BRAFFGFR1WEE1ABL1RIPK2 | |
| SCHEMBL29357737 | 0.87 | BRAF (0.50) | BRAFFGFR1WEE1ABL1RIPK2 | |
| SCHEMBL22200682 | 0.84 | FGFR1 (0.44) | BRAFFGFR1WEE1ABL1 | |
| SCHEMBL25035602 | 0.78 | BRAF (0.49) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941919-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES | Genentech, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |