Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | WEE1 | P30291 | 9/20 | 0.43 |
| ▸ | ABL1 | P00519 | 5/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200335 | 0.87 | WEE1 (0.34) | FGFR1WEE1ABL1BRAF | |
| SCHEMBL22190845 | 0.84 | BRAF (0.49) | FGFR1WEE1ABL1BRAF | |
| SCHEMBL29356205 | 0.84 | BRAF (0.49) | FGFR1WEE1ABL1BRAF | |
| SCHEMBL22200519 | 0.77 | ERN1 (0.42) | FGFR1WEE1ABL1BRAFSRC | |
| SCHEMBL29353821 | 0.76 | FGFR1 (0.44) | FGFR1WEE1ABL1BRAFSRC | |
| SCHEMBL22190881 | 0.76 | FGFR1 (0.44) | FGFR1WEE1ABL1BRAFSRC | |
| SCHEMBL22200697 | 0.76 | BRAF (0.40) | FGFR1WEE1ABL1BRAFSRC | |
| SCHEMBL21990257 | 0.74 | ABL1 (0.53) | FGFR1WEE1ABL1SRCEGFR | |
| SCHEMBL22200536 | 0.74 | BRAF (0.38) | FGFR1ABL1BRAFSRCEGFR | |
| SCHEMBL22200535 | 0.73 | AKT1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |