Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 7/20 | 0.35 |
| ▸ | AKT2 | P31751 | 7/20 | 0.35 |
| ▸ | ERN1 | O75460 | 2/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.33 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.33 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22191516 | 1.00 | BRAF (0.36) | BRAFCYP17A1AKT1AKT2ERN1 | |
| SCHEMBL25035601 | 0.89 | F2 (0.37) | BRAFCYP17A1ERN1GLO1ALDH1A1 | |
| SCHEMBL29352947 | 0.88 | BRAF (0.36) | BRAFCYP17A1ERN1GLO1ALDH1A1 | |
| SCHEMBL22191327 | 0.88 | BRAF (0.36) | BRAFCYP17A1ERN1GLO1ALDH1A1 | |
| SCHEMBL22200535 | 0.85 | AKT1 (0.35) | AKT1AKT2 | |
| SCHEMBL24558621 | 0.81 | ERN1 (0.51) | BRAFERN1 | |
| SCHEMBL29735923 | 0.81 | ERN1 (0.51) | BRAFERN1 | |
| SCHEMBL22190821 | 0.78 | ERN1 (0.40) | BRAFERN1MAP2K7MAPK8MAP2K4 | |
| SCHEMBL22191003 | 0.78 | ERN1 (0.39) | BRAFERN1GLO1CXCR2 | |
| SCHEMBL29353158 | 0.78 | ERN1 (0.39) | BRAFERN1GLO1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941919-B1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH INC (US) | 2025-12-24 | — | — | EP | disclosed |
| EP-3941919-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES | Genentech, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |