Polymyxin B2

Polymyxin B2

SCHEMBL29356304

CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KDM1A O60341 3/20 0.98
▸ RCOR1 Q9UKL0 2/20 0.98
▸ LDHB P07195 3/20 0.42
▸ TERF2IP Q9NYB0 4/20 0.42
▸ EGFR P00533 1/20 0.40
▸ LCK P06239 1/20 0.40
▸ HKDC1 Q2TB90 1/20 0.39
▸ NPY1R P25929 1/20 0.39
▸ NPY2R P49146 1/20 0.39
▸ NPY4R P50391 1/20 0.39
▸ NPY5R Q15761 1/20 0.39
▸ PSMB5 P28074 2/20 0.39
▸ PSMB2 P49721 1/20 0.39
▸ SSTR2 P30874 3/20 0.38
▸ SSTR4 P31391 3/20 0.38
▸ SSTR5 P35346 3/20 0.38
▸ SSTR1 P30872 1/20 0.38
▸ SSTR3 P32745 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Polymyxin B2 SCHEMBL29514784 1.00 KDM1A (0.98) KDM1ARCOR1LDHBTERF2IPEGFR
SCHEMBL15507051 0.99 KDM1A (1.00) KDM1ARCOR1LDHBTERF2IPEGFR
SCHEMBL136097 0.99 KDM1A (1.00) KDM1ARCOR1LDHBTERF2IPEGFR
SCHEMBL21991628 0.99 KDM1A (1.00) KDM1ARCOR1LDHBTERF2IPEGFR
SCHEMBL7799155 0.99 KDM1A (1.00) KDM1ARCOR1LDHBTERF2IPEGFR
SCHEMBL23626629 0.99 KDM1A (1.00) KDM1ARCOR1LDHBTERF2IPEGFR
SCHEMBL19532503 0.99 KDM1A (1.00) KDM1ARCOR1LDHBTERF2IPEGFR
SCHEMBL16549195 0.99 KDM1A (1.00) KDM1ARCOR1LDHBTERF2IPEGFR
SCHEMBL18902502 0.99 KDM1A (1.00) KDM1ARCOR1LDHBTERF2IPEGFR
SCHEMBL14241069 0.99 KDM1A (1.00) KDM1ARCOR1LDHBTERF2IPEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 10020 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144896-A1 MODIFIED CPG DINUCLEOTIDES FOR RECOMBINANT VIRAL VECTOR PRODUCTION SIREN BIOTECHNOLOGY, INC. (US) 2026-05-28 — — US claimed
EP-4746852-A1 LIPID AGGREGATES FOR INTRAARTICULAR ADMINISTRATION Universität Bern (CH) 2026-05-27 — — EP claimed
CN-122075542-A Application of catalpol and mesenchymal stem cells in preparation of medicines for treating hepatic fibrosis — 2026-05-26 — — CN claimed
CN-122075805-A Anticoagulation anti-infection dialysis catheter coating and preparation method thereof — 2026-05-26 — — CN claimed
US-20260137809-A1 GENE THERAPY VECTORS FOR TREATMENT OF CANCER SIREN BIOTECHNOLOGY INC (US) 2026-05-21 — — US claimed
US-20260137754-A1 APPLICATION OF A COMBINATION DRUG IN THE TREATMENT OF PATHOGENIC BACTERIAL PERSISTENT INFECTIONS NOVOHEALTH SUZHOU BIOTECH CO LTD (CN) 2026-05-21 — — US claimed
CN-122060823-A Method for preparing horse F (ab ') 2 and horse Fab' preparation by multienzyme one-pot method 江西生物制品研究所股份有限公司 2026-05-19 — — CN claimed
CN-122036889-A Cyclized antibacterial peptide CycP-1 of targeted multi-drug resistant klebsiella pneumoniae, composition and application thereof 湖北江夏实验室 2026-05-15 — — CN claimed
EP-4739326-A2 PRODUCTION & SECRETION OF AUXIN-LIKE MOLECULES IN BACTERIA SNIPR Biome ApS (DK) 2026-05-13 — — EP claimed
CN-122012657-A Fermentation method for improving yield of polymyxin B 河北圣雪大成制药有限责任公司 2026-05-12 — — CN claimed
CN-114040773-A Lysin and derivatives thereof having bactericidal activity against pseudomonas aeruginosa in the presence of human serum 康特拉费克特公司 2022-02-11 — — CN claimed
CN-114040779-A Conjugates of cell binding molecules containing branched linkers and cytotoxic agents 杭州多禧生物科技有限公司 2022-02-11 — — CN claimed
WO-2022031577-A1 THERMO-SENSITIVE PERMEATION ENHANCING FORMULATIONS FOR DRUG DELIVERY CHILDREN'S MEDICAL CENTER CORPORATION (US) 2022-02-10 — — WO claimed
EP-3947417-A1 NOVEL COMPOUNDS AND THERAPEUTIC USES THEREOF Centauri Therapeutics Limited (GB) 2022-02-09 — — EP claimed
CN-113209364-B Polymer hydrogel with tissue light healing function and preparation and application thereof 四川大学 2022-02-08 — — CN claimed
US-20220031625-A1 OPHTHALMIC COMPOSITIONS FOR DELIVERING MEIBUM-LIKE MATERIALS ALTAIRE PHARMACEUTICALS, INC. 2022-02-03 — — US claimed
CN-113980072-A Beta-glucosidase fluorogenic substrate CFMU-Glu and preparation method and application thereof 广东省科学院微生物研究所(广东省微生物分析检测中心) 2022-01-28 — — CN claimed
US-20220023419-A1 INHIBITING INFLAMMATION FRED HUTCHINSON CANCER CENTER 2022-01-27 — — US claimed
EP-3941206-A1 NEW USES OF A MUTATED LACTONASE, AND COMPOSITIONS Fondation Méditerranée Infection (FR) 2022-01-26 — — EP claimed
EP-3344232-B1 MICELLES FOR MUCOADHESIVE DRUG DELIVERY UNIV MCMASTER (CA) 2022-01-26 — — EP claimed
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