SCHEMBL29357315

SCHEMBL29357315

NC(=O)c1cc(F)cc2c1C(=O)N(C1CCN(C3CCC(F)(F)CC3)CC1)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 12/20 1.00
PARP2 Q9UGN5 5/20 1.00
CYP2D6 P10635 1/20 1.00
CYP2B6 P20813 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL571003 1.00 PARP1 (1.00) PARP1PARP2CYP2D6CYP2B6
SCHEMBL15662387 0.92 PARP1 (0.85) PARP1PARP2CYP2D6CYP2B6
SCHEMBL15662088 0.91 PARP1 (0.83) PARP1PARP2CYP2D6CYP2B6
SCHEMBL1881724 0.91 PARP1 (1.00) PARP1PARP2CYP2D6CYP2B6
SCHEMBL1860629 0.90 PARP1 (1.00) PARP1PARP2CYP2D6CYP2B6
SCHEMBL15662751 0.88 PARP1 (0.79) PARP1PARP2CYP2D6CYP2B6
SCHEMBL1865934 0.88 PARP1 (0.79) PARP1PARP2CYP2D6CYP2B6
SCHEMBL1876306 0.87 PARP1 (0.77) PARP1PARP2CYP2D6CYP2B6
SCHEMBL30417915 0.87 PARP1 (0.77) PARP1PARP2CYP2D6CYP2B6
SCHEMBL1874517 0.87 PARP1 (0.77) PARP1PARP2CYP2D6CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 173 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106998-A1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)-TARGETED POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITOR AND RELATED COMPOSITION AND METHOD OF USE PURDUE RESEARCH FOUNDATION (US) 2026-05-21 WO claimed
EP-4739310-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) INHIBITOR COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-05-13 EP claimed
US-20250381202-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY ZOUNEK ALEX (DE) 2025-12-18 US claimed
CN-120077031-A Prodrug kit for multitube concurrent chemotherapy 亚历克斯·祖内克 2025-05-30 CN claimed
EP-4551565-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY Zounek, Alex (DE) 2025-05-14 EP claimed
WO-2025007955-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) INHIBITOR COMBINATIONS AND USES THEREOF INSILICO MEDICINE IP LIMITED (CN) 2025-01-09 WO claimed
WO-2024217502-A1 METHIONINE ADENOSYLTRANSFERASE 2A (MAT2A) INHIBITOR COMBINATIONS AND USES THEREOF INSILICO MEDICINE IP LIMITED (CN) 2024-10-24 WO claimed
WO-2024137738-A1 COMBINATIONS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS AND HETEROAROTINOIDS AND METHODS OF USE AS CANCER TREATMENTS THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2024-06-27 WO claimed
WO-2024008833-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY ZOUNEK ALEX (DE) 2024-01-11 WO claimed
US-20230293565-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2023-09-21 US claimed
CN-116249520-A Blocking replication of SARS-COV-2 and other pathogenic viruses using WNT/beta-catenin pathway inhibitors 阿尔伯塔大学理事会 2023-06-09 CN claimed
EP-4188378-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES The Governors of the University of Alberta (CA) 2023-06-07 EP claimed
US-20230123585-A1 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING CANCER USING DEUBIQUITINASE INHIBITORS UNIV CHICAGO (US) 2023-04-20 US claimed
WO-2022020967-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2022-02-03 WO claimed
EP-4048809-B1 SYSTEMS AND METHODS FOR PREDICTING THERAPEUTIC SENSITIVITY TEMPUS AI INC (US) 2026-05-27 EP disclosed
WO-2026106998-A1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)-TARGETED POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITOR AND RELATED COMPOSITION AND METHOD OF USE PURDUE RESEARCH FOUNDATION (US) 2026-05-21 WO disclosed
CN-122059926-A Heterocyclic degradation determinants for target protein degradation C4医药公司 2026-05-19 CN disclosed
CN-112569233-B Application of PARP inhibitor PJ34 in preparation of fish rhabdovirus resistant product 中国水产科学研究院黑龙江水产研究所 2022-03-01 CN disclosed
WO-2022020967-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2022-02-03 WO disclosed
EP-3941481-A1 COMPOSITIONS COMPRISING A PHOSPHORUS DERIVATIVE OF NICOTINAMIDE RIBOSIDE AND METHODS FOR MODULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE Metro International Biotech, LLC (US) 2022-01-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250381202-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY KIT, CTSL, PAICS PARP1 534/4885PARP2 927/4885CYP2D6 2150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.