Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.75 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762127 | 0.88 | BRAF (0.71) | BRAFFLT1KDRKCNH2 | |
| SCHEMBL3763280 | 0.86 | BRAF (1.00) | BRAFKDR | |
| SCHEMBL2931964 | 0.83 | BRAF (1.00) | BRAFKCNH2 | |
| SCHEMBL3755139 | 0.83 | BRAF (1.00) | BRAFKCNH2 | |
| SCHEMBL2935597 | 0.82 | BRAF (0.60) | BRAFCSF1R | |
| SCHEMBL3755752 | 0.82 | BRAF (0.62) | BRAFFLT1KDRCSF1R | |
| SCHEMBL2926476 | 0.80 | BRAF (0.54) | BRAF | |
| SCHEMBL3759453 | 0.79 | BRAF (0.72) | BRAFFLT1KDRKCNH2 | |
| SCHEMBL2935796 | 0.78 | BRAF (0.54) | BRAF | |
| SCHEMBL2935245 | 0.78 | BRAF (0.72) | BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |