Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.54 |
| ▸ | CCNC | P24863 | 3/20 | 0.39 |
| ▸ | CDK8 | P49336 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762135 | 0.88 | BRAF (0.52) | BRAFCCNCCDK8PIK3CAMAPK13 | |
| SCHEMBL3755761 | 0.81 | BRAF (0.45) | BRAFCCNCCDK8PIK3CAMAPK13 | |
| SCHEMBL2935779 | 0.78 | BRAF (0.75) | BRAF | |
| SCHEMBL3759457 | 0.78 | BRAF (0.52) | BRAFCCNCCDK8 | |
| SCHEMBL2935597 | 0.76 | BRAF (0.60) | BRAFCCNCCDK8PIK3CAATR | |
| SCHEMBL3762127 | 0.73 | BRAF (0.71) | BRAF | |
| SCHEMBL3763280 | 0.70 | BRAF (1.00) | BRAF | |
| SCHEMBL15925256 | 0.67 | ALDH1A1 (0.43) | BRAFPIK3CAATRADKKMT2A | |
| SCHEMBL18256822 | 0.67 | MET (0.60) | BRAFCDK8MAPK13 | |
| SCHEMBL2928516 | 0.66 | BRAF (0.52) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |