Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755787 | 0.85 | BRAF (0.51) | BRAFAURKA | |
| SCHEMBL2936181 | 0.83 | BRAF (0.59) | BRAFMEN1KMT2A | |
| SCHEMBL1793446 | 0.78 | BRAF (0.53) | BRAFMEN1KMT2A | |
| SCHEMBL3755791 | 0.77 | BRAF (0.53) | BRAFAURKA | |
| SCHEMBL2934374 | 0.76 | BRAF (0.58) | BRAF | |
| SCHEMBL3754116 | 0.74 | BRAF (0.48) | BRAFAURKA | |
| SCHEMBL2926401 | 0.73 | BRAF (0.57) | BRAF | |
| SCHEMBL12847041 | 0.70 | BRAF (0.48) | BRAF | |
| SCHEMBL3759379 | 0.70 | BRAF (0.70) | BRAF | |
| SCHEMBL9909762 | 0.69 | BRAF (0.48) | BRAFMEN1KMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |