Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3754512 | 0.86 | BRAF (0.60) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL2928625 | 0.85 | BRAF (0.59) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL2936853 | 0.84 | BRAF (0.58) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL2935908 | 0.83 | BRAF (0.50) | BRAFMEN1KMT2A | |
| SCHEMBL3753709 | 0.78 | BRAF (0.71) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL1793446 | 0.78 | BRAF (0.53) | BRAFMEN1KMT2A | |
| SCHEMBL2935957 | 0.76 | BRAF (0.59) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL3757661 | 0.75 | BRAF (1.00) | BRAF | |
| SCHEMBL2935691 | 0.74 | BRAF (0.58) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL2977287 | 0.74 | BRAF (0.77) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |