Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.43 |
| ▸ | RAF1 | P04049 | 12/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | ARAF | P10398 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22468354 | 1.00 | BRAF (0.43) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22468380 | 0.88 | BRAF (0.47) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488550 | 0.87 | BRAF (0.48) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL25594240 | 0.83 | BRAF (0.54) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL25594237 | 0.82 | BRAF (0.46) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22468361 | 0.82 | RAF1 (0.43) | BRAFRAF1 | |
| SCHEMBL25594439 | 0.81 | BRAF (0.45) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22468356 | 0.80 | BRAF (0.64) | BRAFRAF1 | |
| SCHEMBL22468357 | 0.79 | BRAF (0.60) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22612948 | 0.78 | RAF1 (0.62) | BRAFRAF1PDGFRBARAFDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |