SCHEMBL2936075

SCHEMBL2936075

O=C1NC2(CCN(C(=O)c3ccc(Cl)cc3)CC2)N[C@@H]1Cc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
LMNA P02545 1/20 0.47
CCR8 P51685 1/20 0.46
KCNH2 Q12809 1/20 0.46
IP6K1 Q92551 1/20 0.45
IP6K3 Q96PC2 1/20 0.45
IP6K2 Q9UHH9 1/20 0.45
PKLR P30613 1/20 0.45
MGLL Q99685 3/20 0.45
CHRM2 P08172 2/20 0.45
CHRM3 P20309 2/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
RIPK1 Q13546 1/20 0.44
GAA P10253 2/20 0.43
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1801856 1.00 ALDH1A1 (0.47) ALDH1A1LMNACCR8KCNH2IP6K1
SCHEMBL1800555 1.00 ALDH1A1 (0.47) ALDH1A1LMNACCR8KCNH2IP6K1
Hydrochloric Acid SCHEMBL1800924 0.99 ALDH1A1 (0.47) ALDH1A1LMNACCR8KCNH2IP6K1
SCHEMBL1801636 0.87 KMT2A (0.43) ALDH1A1MEN1KMT2ARIPK1GAA
SCHEMBL1803261 0.87 USP2 (0.43) ALDH1A1LMNAKCNH2MGLLCHRM2
SCHEMBL1810855 0.85 NPC1 (0.52) LMNA
SCHEMBL1803253 0.85 CYP2C9 (0.57) ALDH1A1MGLLCHRM2KMT2AGAA
SCHEMBL2936432 0.82 GAA (0.51) ALDH1A1LMNAKMT2AGAASMN1; SMN2
SCHEMBL1801535 0.82 GAA (0.51) ALDH1A1LMNAKMT2AGAASMN1; SMN2
Hydrochloric Acid SCHEMBL1801502 0.81 GAA (0.50) ALDH1A1LMNAKMT2AGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1730147-B1 SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY GRUENENTHAL GMBH (DE) 2010-02-03 EP claimed
WO-2005095402-A9 SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY GRUENENTHAL GMBH (DE) 2009-06-11 WO claimed
EP-1730147-B1 SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY GRUENENTHAL GMBH (DE) 2010-02-03 EP disclosed
WO-2005095402-A9 SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY GRUENENTHAL GMBH (DE) 2009-06-11 WO disclosed
EP-1730147-A1 SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY Grünenthal GmbH (DE) 2006-12-13 EP disclosed
WO-2005095402-A1 SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY Grünenthal GmbH (DE) 2005-10-13 WO disclosed