Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926476 | 0.92 | BRAF (0.54) | BRAF | |
| SCHEMBL3057585 | 0.87 | BRAF (0.49) | BRAFKDR | |
| SCHEMBL3756160 | 0.79 | BRAF (0.55) | BRAFKDR | |
| SCHEMBL2935245 | 0.79 | BRAF (0.72) | BRAFKDR | |
| SCHEMBL15543233 | 0.77 | MAPK14 (0.50) | BRAFKDRKITPDGFRA | |
| SCHEMBL2928507 | 0.77 | BRAF (0.71) | BRAF | |
| SCHEMBL16740695 | 0.76 | BRAF (0.70) | BRAF | |
| SCHEMBL2935779 | 0.75 | BRAF (0.75) | BRAFKDR | |
| SCHEMBL2926569 | 0.74 | KDR (0.47) | BRAFKDRKITPDGFRAFGFR2 | |
| SCHEMBL9909768 | 0.73 | PLAU (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |