Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762437 | 0.93 | EPHX1 (0.49) | EPHX1RAB9ASMN1; SMN2NPC1EPHX2 | |
| SCHEMBL3759377 | 0.91 | PTPN1 (0.46) | EPHX1RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL3204480 | 0.87 | EPHX1 (0.50) | EPHX1RAB9ASMN1; SMN2NPC1EPHX2 | |
| Carbamic Acid SCHEMBL4557656 | 0.86 | SMN1; SMN2 (0.39) | EPHX1RAB9ASMN1; SMN2NPC1EPHX2 | |
| SCHEMBL3225753 | 0.85 | EPHX1 (0.49) | EPHX1SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL2936042 | 0.85 | PTPN1 (0.42) | EPHX1RAB9ASMN1; SMN2NPC1EPHX2 | |
| SCHEMBL2936238 | 0.81 | PTPN1 (0.39) | SMN1; SMN2TP53ATMPTPN1ALDH1A1 | |
| SCHEMBL3205299 | 0.78 | MEN1 (0.48) | RAB9AMEN1KMT2APTPN1ALDH1A1 | |
| SCHEMBL2936155 | 0.78 | PTPN1 (0.47) | SMN1; SMN2NPC1TSHRKMT2APTPN1 | |
| SCHEMBL3226383 | 0.78 | PTPN1 (0.47) | PTPN1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227245-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | Novartis AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068689-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2009-06-04 | — | — | WO | disclosed |