Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2936239 | 0.86 | EPHX1 (0.48) | SMN1; SMN2EPHX2EPHX1NPC1RAB9A | |
| SCHEMBL2935066 | 0.81 | NPC1 (0.51) | SMN1; SMN2POLBEPHX2EPHX1NPC1 | |
| SCHEMBL3762437 | 0.80 | EPHX1 (0.49) | SMN1; SMN2POLBEPHX2EPHX1NPC1 | |
| SCHEMBL3759377 | 0.78 | PTPN1 (0.46) | SMN1; SMN2EPHX1NPC1RAB9AMEN1 | |
| SCHEMBL3262018 | 0.77 | EPHX2 (0.52) | SMN1; SMN2POLBEPHX2EPHX1NPC1 | |
| SCHEMBL2933013 | 0.76 | PTPN1 (0.47) | MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3204480 | 0.76 | EPHX1 (0.50) | SMN1; SMN2EPHX2EPHX1NPC1RAB9A | |
| SCHEMBL3225753 | 0.74 | EPHX1 (0.49) | SMN1; SMN2EPHX1TP53MEN1KMT2A | |
| SCHEMBL2936042 | 0.73 | PTPN1 (0.42) | SMN1; SMN2EPHX2EPHX1NPC1RAB9A | |
| SCHEMBL2936238 | 0.70 | PTPN1 (0.39) | SMN1; SMN2POLBTP53ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089026-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070552-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | NOVARTIS AG (CH) | 2008-06-12 | — | — | WO | disclosed |