SCHEMBL2936247

SCHEMBL2936247

[c]1cnc(-c2nccs2)o1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.39
LOXL2 Q9Y4K0 1/20 0.35
CYP2A6 P11509 1/20 0.35
HSP90AA1 P07900 1/20 0.34
ADORA2A P29274 3/20 0.34
ADORA1 P30542 2/20 0.34
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
NOS1 P29475 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ADRB2 P07550 1/20 0.33
RAB9A P51151 1/20 0.33
SMPD3 Q9NY59 1/20 0.32
FBP1 P09467 1/20 0.31
PDK1 Q15118 1/20 0.31
METAP1 P53582 1/20 0.31
ESR1 P03372 1/20 0.30
ESR2 Q92731 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL967548 0.71 PDPK1 (0.38) PDPK1LOXL2CYP2A6HSP90AA1ADORA2A
SCHEMBL102331 0.69 PDPK1 (0.59) PDPK1LOXL2CYP2A6HSP90AA1ADORA2A
SCHEMBL30534095 0.67 PDPK1 (0.56) PDPK1LOXL2CYP2A6HSP90AA1ADORA2A
SCHEMBL30632310 0.67 PDPK1 (0.56) PDPK1LOXL2CYP2A6HSP90AA1ADORA2A
SCHEMBL31556353 0.67 PDPK1 (0.56) PDPK1LOXL2CYP2A6HSP90AA1ADORA2A
SCHEMBL1559450 0.67 PDPK1 (0.42) PDPK1LOXL2CYP2A6HSP90AA1ADORA2A
SCHEMBL9454512 0.67 PDPK1 (0.42) PDPK1LOXL2CYP2A6HSP90AA1ADORA2A
SCHEMBL9454056 0.67 RAB9A (0.41) ALDH1A1TSHRHSD17B10RAB9A
SCHEMBL570272 0.64 NOTUM (0.39) PDPK1LOXL2CYP2A6HSP90AA1TSHR
SCHEMBL17701190 0.64 PDPK1 (0.43) PDPK1LOXL2CYP2A6HSP90AA1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1997491-B1 Method for inhibiting tumor metastasis INFLAMMATION RES CT COMPANY LT (JP) 2010-09-22 EP disclosed
EP-1997491-A1 Method for inhibiting tumor metastasis Inflammation Research Center Company Ltd. (JP) 2008-12-03 EP disclosed
EP-1765333-A4 METHOD FOR INHIBITING TUMOR METASTASIS INFLAMMATION RES CT COMPANY LT (JP) 2008-06-18 EP disclosed
EP-1765333-A1 METHOD FOR INHIBITING TUMOR METASTASIS Inflammation Research Center Company Ltd. (JP) 2007-03-28 EP disclosed
WO-2006019874-A1 METHOD FOR INHIBITING TUMOR METASTASIS INFLAMMATION RESEARCH CENTER COMPANY LTD. (JP) 2006-02-23 WO disclosed
EP-0835257-B1 INTERMEDIATES AND PROCESS FOR THE MANUFACTURE OF CAMPTOTHECIN DERIVATIVES (CPT-11) AND RELATED COMPOUNDS UPJOHN CO (US) 2002-09-25 EP disclosed
US-6444820-B1 ANTICARCINOGENIC AGENTS HENEGAR KEVIN E (US) 2002-09-03 US disclosed
US-6121451-A Intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds PHARMACIA & UPJOHN COMPANY (US) 2000-09-19 US disclosed
EP-0863907-A1 CYCLOANTHELMINTIC INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1998-09-16 EP disclosed
US-5776950-A PARASITICIDES; MICROBIOCIDES PHARMACIA & UPJOHN COMPANY (US) 1998-07-07 US disclosed
EP-0835257-A1 NOVEL INTERMEDIATES AND PROCESS FOR THE MANUFACTURE OF CAMPTOTHECIN DERIVATIVES (CPT-11) AND RELATED COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 1998-04-15 EP disclosed
WO-1997009331-A1 CYCLOANTHELMINTIC INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1997-03-13 WO disclosed
WO-1996031513-A1 NOVEL INTERMEDIATES AND PROCESS FOR THE MANUFACTURE OF CAMPTOTHECIN DERIVATIVES (CPT-11) AND RELATED COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 1996-10-10 WO disclosed