SCHEMBL2936256

SCHEMBL2936256

O=C(Nc1ccccc1Br)c1ccccc1C(F)(F)F

nearest known ligand 0.78

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.78
LMNA P02545 1/20 0.63
GAA P10253 1/20 0.63
RXFP1 Q9HBX9 2/20 0.58
KMT2A Q03164 2/20 0.57
PTGS1 P23219 1/20 0.52
KCNK3 O14649 1/20 0.52
KCNK9 Q9NPC2 1/20 0.52
MEN1 O00255 1/20 0.50
PDK1 Q15118 1/20 0.50
PDK2 Q15119 1/20 0.50
PDK3 Q15120 1/20 0.50
PDK4 Q16654 1/20 0.50
TAS2R14 Q9NYV8 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.49
PTPRC P08575 1/20 0.49
RECQL P46063 1/20 0.48
KDM4E B2RXH2 1/20 0.48
ATM Q13315 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2940693 0.83 SMN1; SMN2 (0.61) SMN1; SMN2LMNAGAARXFP1KMT2A
SCHEMBL27582898 0.83 LMNA (0.67) SMN1; SMN2LMNAGAARXFP1KMT2A
SCHEMBL28695522 0.81 KMT2A (0.70) SMN1; SMN2LMNAGAARXFP1KMT2A
SCHEMBL12918684 0.81 SMN1; SMN2 (0.64) SMN1; SMN2LMNAGAARXFP1KMT2A
SCHEMBL21311188 0.81 HTT (0.62) SMN1; SMN2LMNAGAARXFP1KMT2A
SCHEMBL13477980 0.81 SMN1; SMN2 (0.60) SMN1; SMN2LMNAGAARXFP1KMT2A
SCHEMBL27541149 0.80 SMN1; SMN2 (0.59) SMN1; SMN2LMNAGAARXFP1KMT2A
SCHEMBL14559968 0.80 SMN1; SMN2 (0.59) SMN1; SMN2LMNAGAARXFP1KMT2A
SCHEMBL26066184 0.79 SMN1; SMN2 (0.57) SMN1; SMN2LMNAGAARXFP1KMT2A
SCHEMBL2937452 0.78 SMN1; SMN2 (0.56) SMN1; SMN2LMNAGAARXFP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1480516-B1 MICROBICIDAL AGENTS ON THE BASIS OF BIPHENYL BENZAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2010-02-03 EP disclosed
EP-1480516-B1 MICROBICIDAL AGENTS ON THE BASIS OF BIPHENYL BENZAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2010-02-03 EP disclosed
US-7186862-B2 Microbicidal agents on the basis of biphenylbenzamide derivatives BAYER CROPSCIENCE AG (DE) 2007-03-06 US disclosed
US-7186862-B2 Microbicidal agents on the basis of biphenylbenzamide derivatives BAYER CROPSCIENCE AG (DE) 2007-03-06 US disclosed
US-7186862-B2 Microbicidal agents on the basis of biphenylbenzamide derivatives BAYER CROPSCIENCE AG (DE) 2007-03-06 US disclosed
US-20050119347-A1 Microbicidal agents on the basis of biphenyl benzamide derivatives BAYER INTELLECTUAL PROPERTY GMBH (DE) 2005-06-02 US disclosed
EP-1480516-A1 MICROBICIDAL AGENTS ON THE BASIS OF BIPHENYL BENZAMIDE DERIVATIVES Bayer CropScience AG (DE) 2004-12-01 EP disclosed
WO-2003069995-A1 MICROBICIDAL AGENTS ON THE BASIS OF BIPHENYL BENZAMIDE DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2003-08-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050119347-A1 Microbicidal agents on the basis of biphenyl benzamide derivatives DDT, MSR1, CYP1B1 SMN1; SMN2 3753/4885LMNA 4173/4885GAA 1471/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.