SCHEMBL29363644

SCHEMBL29363644

Fc1c(Br)cccc1Nc1ncnc2cc3c(cc12)OCCO3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31004070 1.00 EGFR (1.00) EGFR
SCHEMBL20865211 1.00 EGFR (1.00) EGFR
SCHEMBL24329439 0.95 EGFR (0.91) EGFR
SCHEMBL24329506 0.93 EGFR (0.87) EGFR
SCHEMBL20865297 0.88 EGFR (1.00) EGFR
SCHEMBL20865247 0.86 EGFR (1.00) EGFR
SCHEMBL20865372 0.86 EGFR (1.00) EGFR
SCHEMBL22427546 0.86 EGFR (0.78) EGFR
SCHEMBL20865303 0.86 EGFR (1.00) EGFR
SCHEMBL20865232 0.85 EGFR (0.74) EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118987016-A Application of antisense oligonucleotide in preparing medicament for treating glioma 北京悦康科创医药科技股份有限公司 2024-11-22 CN claimed
WO-2022020114-A2 METHODS FOR THE PREVENTION AND TREATMENT OF HEARING LOSS TING THERAPEUTICS LLC (US) 2022-01-27 WO claimed
US-20250236596-A1 HYDROXYLAMINE-BASED EGFR INHIBITORS FOR TREATMENT OF CANCER WITH BRAIN METASTASES UNIV GEORGIA (US) 2025-07-24 US disclosed
EP-4587017-A2 HYDROXYLAMINE-BASED EGFR INHIBITORS FOR TREATMENT OF CANCER WITH BRAIN METASTASES University of Georgia Research Foundation, Inc. (US) 2025-07-23 EP disclosed
EP-4578457-A1 PHARMACEUTICAL FOR TREATING AND/OR PREVENTING CANCER Toray Industries, Inc. (JP) 2025-07-02 EP disclosed
CN-119894510-A Hydroxylamine-based EGFR inhibitors for the treatment of brain metastasis 乔治亚大学研究基金会 2025-04-25 CN disclosed
CN-119768182-A Medicine for treating and/or preventing cancer 东丽株式会社 2025-04-04 CN disclosed
WO-2024215467-A9 METHODS FOR THE PREVENTION AND TREATMENT OF HEARING LOSS TING THERAPEUTICS, INC. (US) 2024-12-05 WO disclosed
CN-118987016-A Application of antisense oligonucleotide in preparing medicament for treating glioma 北京悦康科创医药科技股份有限公司 2024-11-22 CN disclosed
US-20240350492-A1 Methods for the Prevention and Treatment of Hearing Loss TING THERAPEUTICS LLC (US) 2024-10-24 US disclosed
WO-2024215467-A1 METHODS FOR THE PREVENTION AND TREATMENT OF HEARING LOSS TING THERAPEUTICS LLC (US) 2024-10-17 WO disclosed
WO-2024059668-A2 HYDROXYLAMINE-BASED EGFR INHIBITORS FOR TREATMENT OF CANCER WITH BRAIN METASTASES UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-03-21 WO disclosed
WO-2024043252-A1 PHARMACEUTICAL FOR TREATING AND/OR PREVENTING CANCER 東レ株式会社 2024-02-29 WO disclosed
WO-2022020114-A2 METHODS FOR THE PREVENTION AND TREATMENT OF HEARING LOSS TING THERAPEUTICS LLC (US) 2022-01-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250236596-A1 HYDROXYLAMINE-BASED EGFR INHIBITORS FOR TREATMENT OF CANCER WITH BRAIN METASTASES EGFR, ERBB2, ERBB3 EGFR 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.