Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.40 |
| ▸ | PTPRA | P18433 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222948 | 0.97 | PTPN1 (0.41) | PTPN1CNR1CNR2DRD2DRD3 | |
| SCHEMBL3216170 | 0.96 | PTPN1 (0.40) | PTPN1CNR1CNR2DRD2DRD3 | |
| SCHEMBL2936384 | 0.94 | PTPN1 (0.39) | PTPN1CNR1CNR2DRD2DRD3 | |
| SCHEMBL4784709 | 0.92 | PTPN1 (0.45) | PTPN1PTPRACNR1CNR2PTPN2 | |
| SCHEMBL3216067 | 0.88 | CNR1 (0.42) | PTPN1CNR1CNR2DRD2DRD3 | |
| SCHEMBL3220485 | 0.87 | PTPN1 (0.43) | PTPN1CNR1CNR2 | |
| SCHEMBL3217932 | 0.86 | CNR1 (0.41) | PTPN1PTPRACNR1CNR2PTPN2 | |
| SCHEMBL3216194 | 0.85 | PTPN1 (0.42) | PTPN1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL2929598 | 0.85 | PTPN1 (0.44) | PTPN1CNR1CNR2DRD2DRD3 | |
| SCHEMBL2930641 | 0.85 | PTPN1 (0.44) | PTPN1CNR1CNR2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227245-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | Novartis AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068689-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2009-06-04 | — | — | WO | disclosed |