Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.60 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838420 | 1.00 | KCNH2 (0.60) | KCNH2CACNA1ICHRNA7CYP2D6SLC6A2 | |
| SCHEMBL29363882 | 0.91 | KCNH2 (0.62) | KCNH2CACNA1ICHRNA7CYP2D6SLC6A2 | |
| SCHEMBL18838393 | 0.91 | KCNH2 (0.62) | KCNH2CACNA1ICHRNA7CYP2D6SLC6A2 | |
| SCHEMBL18860280 | 0.89 | KCNH2 (0.60) | KCNH2CACNA1ICHRNA7CYP2D6SLC6A2 | |
| SCHEMBL18838348 | 0.88 | KCNH2 (0.48) | KCNH2CACNA1ICHRNA7SLC6A4OPRM1 | |
| SCHEMBL29363863 | 0.87 | KCNH2 (0.61) | KCNH2CACNA1IMEN1KMT2ACACNA1H | |
| SCHEMBL18838392 | 0.87 | KCNH2 (0.61) | KCNH2CACNA1IMEN1KMT2ACACNA1H | |
| SCHEMBL18838325 | 0.86 | KCNH2 (0.62) | KCNH2CACNA1ICYP2D6CACNA1H | |
| SCHEMBL18838333 | 0.86 | CACNA1I (0.45) | KCNH2CACNA1ICHRNA7TAS1R3TAS1R2 | |
| SCHEMBL18838368 | 0.84 | CARM1 (0.46) | KCNH2CACNA1IOPRM1OPRL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108289886-B | Ion channel inhibiting compounds, pharmaceutical formulations and uses | 安华赛公司 | 2022-01-28 | — | — | CN | disclosed |