Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162909 | 1.00 | KDM4E (0.49) | KDM4EPTGS1PTGS2NOTUMUSP2 | |
| SCHEMBL30582364 | 0.86 | ADA (0.43) | KDM4EPTGS1PTGS2USP2MAPK1 | |
| SCHEMBL2774450 | 0.81 | KDM4E (0.49) | KDM4EPTGS1PTGS2SMN1; SMN2P4HTM | |
| SCHEMBL27655886 | 0.81 | KDM4E (0.56) | KDM4ENOTUMP4HTMLMNANAPRT | |
| SCHEMBL19991300 | 0.81 | KDM4E (0.49) | KDM4EPTGS1PTGS2P4HTMLMNA | |
| SCHEMBL27648103 | 0.79 | KDM4E (0.48) | KDM4EP4HTMLMNANAPRTL3MBTL1 | |
| SCHEMBL14239715 | 0.79 | KDM4E (0.42) | KDM4EMAPK1LMNA | |
| SCHEMBL4425274 | 0.79 | KMO (0.47) | KDM4E | |
| SCHEMBL14692532 | 0.79 | KDM4E (0.48) | KDM4ENOTUM | |
| SCHEMBL29072990 | 0.79 | NOTUM (0.54) | KDM4ENOTUMSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999205-B | Pyridine compound containing triazolone amide and imidazolone amide structures and application thereof | 辽宁大学 | 2023-09-15 | — | — | CN | disclosed |
| CN-115850268-A | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2023-03-28 | — | — | CN | disclosed |
| CN-110337294-B | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2022-11-01 | — | — | CN | disclosed |
| CN-113999205-A | Pyridine compound containing triazole ketoamide and imidazole amide structures and application thereof | 辽宁大学 | 2022-02-01 | — | — | CN | disclosed |