Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376254 | 1.00 | RIPK2 (0.56) | RIPK2PIK3CDPIK3C2GPIK3CGPDGFRB | |
| SCHEMBL18377044 | 0.84 | RIPK2 (0.69) | RIPK2PIK3CGPDGFRBJAK2BRD4 | |
| SCHEMBL29372255 | 0.84 | RIPK2 (0.69) | RIPK2PIK3CGPDGFRBJAK2BRD4 | |
| SCHEMBL18376246 | 0.84 | JAK2 (0.56) | FGFR4JAK2BRD4CCNA2CDK2 | |
| SCHEMBL29371334 | 0.84 | JAK2 (0.56) | FGFR4JAK2BRD4CCNA2CDK2 | |
| SCHEMBL18377049 | 0.82 | RIPK2 (0.57) | RIPK2PIK3CGJAK2BRD4CDK1 | |
| SCHEMBL18377043 | 0.81 | ACP1 (0.56) | RIPK2FGFR4JAK2BRD4 | |
| SCHEMBL29368456 | 0.81 | ACP1 (0.56) | RIPK2FGFR4JAK2BRD4 | |
| SCHEMBL18377055 | 0.81 | SRC (0.53) | RIPK2PIK3CGPDGFRBSRCFGFR4 | |
| SCHEMBL18376778 | 0.81 | TTK (0.67) | RIPK2JAK2BRD4CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |